Parallel Synthesis of Libraries of Medicinal Interest

John Spencer
University of Greenwich at Medway Chatham ME4 4TB, UK.

Abstract:
Parallel synthetic methods have been applied towards the synthesis of   privileged structures with potential biological activity, notably   oxazoles, benzodiazepines, biphenyls and pyridines. Microwave and   flow-mediated chemistries have been employed to accelerate the synthetic   process and we will describe Suzuki couplings and noel reduction   methodologies. A number of the compounds have been tested against a range  of GPCR, enzyme, neglected disease and oncology targets.